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KMID : 1041220000420010058
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Journal of Sericultural and Entomological Science
2000 Volume.42 No. 1 p.58 ~ p.64
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Effects of Silk Fibroin in Oxdative Stress and Membrane Fluidity in the Liver of SD Rats
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Abstract
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This study was designed to investigate the effects of silk fibroin powder(Mw 500) on oxidative stress and membrane fluidity in liver membranes of rats. Sptague-Dawley(SD) male rats(160±10g) were fed basic diet (control group), and experimental diet (SFP-2.5 and SFP-5.0 groups) added 2.5 and 5.0 g/kg BW/day for 6 weeks. Cholesterol levels resulted in a significant decrease (12.1% and 9.0%, respectively) in the liver mitochondria and microsomes of SFP-5.0 group compared with control group. Membrane fluidity as significantly increased (16.1% and 16.5%, 5.8% and 17.4%) in the liver mitochondria and microsomes of SFP-2.5 and SFP, 5.0 groups compared with control group. Induced oxygen radicals (IOR) in liver microsomes were significantly inhibited(17.0% and 26.6%, respectively) at the SFP-2.5 and SFP-5.0 groups compared with control group, but IOR in liver mitochondria was significantly inhibited about 12.3% at the SWP-400 group only compared with control group. Oxidized protein (OP) levels were dose-dependently decreased (5.4% and 11.6%, 19.0% and 24.4%, respectively) in the river mitochondria and microsomes of SFP-2.5 and SFP-5.0 groups compared with control group. These results suggest that administration of SFP may play and effective role in attenuating an oxidative stress and increasing a membrane fluidity in liver membrancs.
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